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Oxycontin 80Mg Tablets Online according to the federal government’s National Survey on Drug Use and Health. The drug is widely blame for setting off the nation’s prescription opioid epidemic which has claime more than 190 000 lives from overdoses involving OxyContin and other painkillers since 1999.
The internal Purdue documents reviewe by The Times come from court cases and government investigations and include many records seale by the courts. The documents provide a detaile picture of the development and marketing of OxyContin, how Purdue executives respond to complaints that its effects wear off early, and their fears about the financial impact of any departure from 12-hour dosing.
OxyContin taken at 12-hour intervals could be “the perfect recipe for addiction,” said Theodore J. Cicero, a neuropharmacologist at the Washington University School of Medicine in St. Louis and a leading researcher on how opioids affect the brain. “He who sells 40mg” the largest pill available at the time “will win the battle,” the manager wrote. In the training materials reviewe by The Times, little was said about the effect of higher doses on patient health. Those on higher doses of opioids are more likely to overdose, according to numerous research studies. “That becomes a very powerful motivator for people to take more drugs.”
- Purdue has known about the problem for decades.
- The company has held fast to the claim of 12-hour relief, in part to protect its revenue. OxyContin’s market dominance and its high price up to hundreds of dollars per bottle hinge on its 12-hour duration. Without that, it offers little advantage over less expensive painkillers.
- Anything shorter “needs to be nippe in the bud. NOW!!” one manager wrote to her staff.
- That approach creates risks of its own.